Mild cooling of the brain after a head injury prevents the later development of epileptic seizures, according to an animal study reported this month in the 聽Annals of Neurology
Epilepsy can result from genetics or brain damage. Traumatic head injury is the leading cause of acquired epilepsy in young adults. It is often difficult to manage with antiepileptic drugs. The mechanisms 聽behind the onset of epileptic seizures after brain injury are not known . There is currently no treatment to cure it, prevent it, or even limit its severity.
The multi-institutional research team used a rodent model of acquired epilepsy in which animals develop chronic spontaneous recurrent seizures -the hallmark of epilepsy- after a contusive head injury similar to that causing epilepsy in humans. 聽The rats were randomized to either mock-cooling or cooling of the contused brain by no more than 2 Celsius degrees. This degree of cooling, the authors explained, is known to be safe and to decrease mortality of patients with head injury. 聽The rats 聽were then monitored for four months after injury and epilepsy was evaluated by intracranial EEG. The contused brain was cooled continuously with special headsets engineered to passively dissipate heat. No Peltier cells or other power sources for refrigeration were needed.
The investigators report that cooling by just 2 degrees celsius for 5 weeks beginning 3 days after injury virtually abolished the later development of epileptic seizure activity. This effect persisted through the end of the study. The treatment induced no additional pathology or inflammation, and restored neuronal activity depressed by the injury.
鈥淭hese findings demonstrate for the first time that prevention of epileptic seizures after traumatic brain brain injury is possible, and that epilepsy prophylaxis in patients could be achieved more easily than previously thought, said 聽the lead author of the study, 聽Raimondo D鈥橝mbrosio, UW associate professor of neurological surgery. 聽He added that a clinical trial is required to verify the findings in head injury patients.
In addition to D鈥橝mbrosio, 聽the research team from the UW 聽included 聽John W. Miller, professor of neurology and director of the UW Regional Epilepsy Center; 聽聽Nancy R. Temkin, professor of neurological surgery and biostatistics; and 聽Jeffrey G. Ojemann, professor of neurological surgery. Other members of the team were 聽Steven M. Rothman, professor of pediatrics and director, Clinical Neurosciences in Pediatrics at the University of Minnesota聽 and聽 Matthew D. Smyth, professor of pediatrics and neurosurgery at Washington University in St. Louis.
Their 鈥淢ild passive focal cooling prevents epileptic seizures after head injury in rats鈥� was funded by CURE Epilepsy in partnership with the United States Army Medical Research and Materiel Command.